The Future of Radiation Therapy for Bladder Cancer

Dattoli Cancer Center

September 6, 2022

Radiation Therapy

Future studies will examine potential markers of tumors, including a protein called MRE11, which plays a vital role in the cellular response to DNA damage induced by radiation. These findings could help doctors design strategies that preserve the bladder after radiation therapy. This will be especially useful for patients because removing the bladder can have significant consequences for the patient’s life.

Intensity-modulated radiation therapy

The target volume for IMRT treatment of bladder cancer was a CTV that contained the tumor and bladder wall, as well as vascular structures in the pelvis and obturator lymph nodes.Non-isotropic edges. First-phase therapy targeted 15 cm surrounding the tumor.Multileaf collimators molded the treatment field.

The volume of the bladder changed dramatically during treatment. This was essential for the researchers who wanted to determine if IMRT could reduce the volume of standard chemoradiation. 116 individuals with muscle-invasive bladder cancer received CRT or IMRT. Patients were telephoned after therapy.

Pembrolizumab

Radiation therapy is a type of treatment that is given to treat cancer. Radiation therapy uses high-energy x-rays or other particles to kill cancer cells. The treatment schedule usually includes several treatments over a certain period. Treatment is often performed before or after surgery. The goal of treatment is to prevent cancer from returning or spreading.

The study enrolled 270 patients. Twenty-eight patients had tumors in the upper tract, and 232 in the lower lot. Of these patients, 61 had undergone prior TC or nephroureterectomy.

Intravesical chemotherapy

Intravesical chemotherapy is one treatment option for patients with advanced bladder cancer. It involves delivering a therapeutic drug directly into the bladder through a catheter. The therapy is administered weekly for a few weeks. After therapy, empty the bladder.

Treatment for bladder cancer usually involves multiple treatments, including chemotherapy. Six-week intravenous treatments are common. After the initial treatment, patients may need additional booster treatments, such as immunotherapy or BCG, and maintenance therapy. If cancer spreads beyond the bladder, surgery is recommended.

Intravesical chemotherapy is usually an outpatient procedure but might be surgery. Patients should empty their bladder before the procedure to avoid foreign items. Once the bladder is empty, a healthcare expert will place a sterile catheter into the urethra to inject drugs.During the procedure, male patients may experience an involuntary reflex erection, although this may go away with deep breathing or thinking about something else.

MRI tumor definition

MRI tumor definition in bladder cancer can help the clinician make an accurate diagnosis. It uses multiple imaging techniques, such as T2-weighted spin-echo sequences and diffusion-tensor imaging (DCE). In the first step, the doctor will evaluate the MRI tumor signal. Using this, the clinician can determine the tumor’s size, shape, and configuration.

MRI is a valuable tool for tumor definition, but it is not a replacement for the other tests for diagnosis. For example, transurethral resection biopsy is still the most accurate way to determine the extent of the tumor. Other cancer diagnostic techniques include CT urography and cystoscopy.

MRI of the bladder shows a polypoid mass in the left part of the trigone. This mass has a hypo signal on T2-weighted SE, with the wall of the trigone and the surrounding fat space disrupted. This demonstrates a tumor that has invaded the muscles and fat without involving the ureter.

Partial bladder treatment

Partial bladder radiotherapy can be a good option for patients with bladder cancer. Lower radiation dosage preserves tumor margins. In addition, image-guided radiotherapy reduces toxicity, and incidental quantities to nodes are less. However, this approach is inappropriate for all patients because there is no evidence that it provides improved local control or survival.

In addition to radiation therapy, patients with bladder cancer can also get chemotherapy. IV or oral administration is common. The drugs travel through the bloodstream so that they may kill cancer cells outside the bladder. The cycles may last months.